Made with water, glycerin, and sodium polyacrylate, it is latex-free and non-toxic. This reusable nurse-shaped hot/cold aqua bead gel therapy pack provides temporary relief for sore muscles. This product is refrigerator friendly. To use cold, place in the fridge prior to application. To use hot, immerse gel pack in hot water for five minutes. Over 5000pcs, the price is based on door to door sea shipment + express.